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Hereditary motor sensory neuropathies: charcot-marie-tooth. Genetics PMP-22 Gene mutation types Duplication of one PMP-22 gene (3 total copies of PMP-22): Types . Segmental duplication in gene area. Due to unequal crossing over of chromosomes during meiosis; Duplication size Varies among patients
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Biology and diseases of mice. The laboratory mouse was employed in comparative anatomical studies as early as the 17th century, but accelerated interest in biology during the 19th century, a renewed interest in Mendelian genetics, and the research requirement for a small, economical mammal that was easily housed and bred were instrumental in the development of the ‘modern’ laboratory mouse.
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